Asian Journal of Transfusion Science
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ORIGINAL ARTICLE
Year : 2007  |  Volume : 1  |  Issue : 2  |  Page : 56-58

Study of 25 cases of exchange transfusion by reconstituted blood in hemolytic disease of newborn


1 Blood Bank, Department of Pathology, GRMC, India
2 Emergency Blood Bank, Gwalior, India
3 Blood Bank, Department of Paediatrics, GRMC, India
4 Kilkari Nursing Home, Gwalior, India

Correspondence Address:
D C Sharma
Component in Charge, Blood Bank, 2B, JAH Campus, Gwalior, MP
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-6247.33448

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This study was aimed to review and establish the practice of exchange transfusion (ET) with reconstituted blood in neonates and to observe fall of bilirubin and its comparison with related studies. Twenty-five neonates diagnosed as hemolytic disease of newborn (HDN) were selected for this study, in which exchange transfusion was carried out as one of the treatments for hyperbilirubinemia. Out of the 25 cases, 15 were of Rhesus (Rh) HDN, while ABO and other blood groups constituted 6 and 4 HDN cases respectively. First, the neonates' and mother's blood samples were subjected to relevant investigations. After that, for neonates having Rh HDN, O Rh negative cells suspended in AB plasma were given, O Rh positive cells suspended in AB plasma were given to ABO HDN; and O positive cells, which were indirect Coomb's cross-matched compatible with neonates' and mother's serum / plasma, suspended in AB plasma were given to the neonates having HDN because of other blood group antibodies. The exchange transfusion (ET) was carried out taking all aseptic precautions by Push-Pull technique with double-volume exchange transfusion method. The average post-exchange fall in serum indirect bilirubin was (52.01%) in all 25 cases, which was found to be more significant than the previous studies. Looking into the superiority of the exchange transfusion in HDN by reconstituted blood, the reconstituted blood can be modified and supplied as per the requirement and conditions.


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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006