Asian Journal of Transfusion Science
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ORIGINAL ARTICLE
Year : 2011  |  Volume : 5  |  Issue : 1  |  Page : 18-22

Hexamoll DINCH plasticised PVC containers for the storage of platelets


1 Consultant, R&D Center, Terumo Penpol Ltd, Trivandrum, Kerala, India
2 Deputy Manager, R&D Centre, Terumo Penpol Ltd, Trivandrum, Kerala, India
3 Senior Executive, R&D Centre, Terumo Penpol Ltd, Trivandrum, Kerala, India

Correspondence Address:
C S Bhaskaran Nair
Consultant, R&D Centre, Terumo Penpol Ltd, Trivandrum, Kerala
India
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Source of Support: Terumo Penpol, Conflict of Interest: None


DOI: 10.4103/0973-6247.75972

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Introduction : Containers for the storage of platelets are made using polyvinyl chloride plasticised with di, (2-ethyl hexyl) phthalate, n-butyryl, tri (n-hexyl) citrate and tri (2-ethyl hexyl) mellitate or using special poly olefins without plasticiser. Of these, the first two have disadvantages such as plasticiser leaching and impairment of platelet function. Polyolefin bags cannot be HF welded or steam sterilized. Mellitate plasticised bags can store platelets well for five days but they are not completely phthalate free. Research and Development: We have developed a new generation of containers made of PVC plasticised with the non DEHP, non aromatic plasticiser,1,2- Cyclohexanedicarboxylic acid, diisononyl ester (Hexamoll DINCH) which can store platelets without loss of function for at least six days. Observation: The present studies show that DINCH plasticised PVC bags (TPL-167) are well suited for the storage of platelet concentrates for more than five days. Conclusion: The present studies show that the PVC plasticised with the non phthalate, non aromatic, non toxic plasticiser DINCH is a viable alternative to other existing containers for the storage of platelets for more than five days.


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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006