Asian Journal of Transfusion Science
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LETTER TO THE EDITOR Table of Contents   
Year : 2014  |  Volume : 8  |  Issue : 1  |  Page : 65-66
Failure of detection of leakage by cell separator during plateletpheresis procedures


Department of Transfusion Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Date of Web Publication7-Feb-2014
 

How to cite this article:
Patidar G, Hans R, Mittal K, Malhotra S, Sharma RR, Marwaha N. Failure of detection of leakage by cell separator during plateletpheresis procedures. Asian J Transfus Sci 2014;8:65-6

How to cite this URL:
Patidar G, Hans R, Mittal K, Malhotra S, Sharma RR, Marwaha N. Failure of detection of leakage by cell separator during plateletpheresis procedures. Asian J Transfus Sci [serial online] 2014 [cited 2022 Dec 2];8:65-6. Available from: https://www.ajts.org/text.asp?2014/8/1/65/126703


Sir,

Cell separators are provided with sensitive leak detectors to give audiovisual alarms in case of leakage during apheresis procedures. Here, we report two plateletpheresis procedures where the system failed to detect the same in time.

We report our experience of two plateletpheresis procedures on cell separator Trima Accel, where leakage alarm appeared at platelet collection of 2.5 × 10 11 and 1.8 × 10 11 yield against a target of 6 × 10 11 , processing 1,758 ml volume of blood in first procedure and 1,023 ml volume of blood in second procedure at a flow rate of 120 ml/min. Both procedures were terminated without rinse back. The procedures were performed during routine hours. Alarm appeared after 35 min in first and 28 min in second procedure, installation and priming of the kits were uneventful. On opening the centrifuge door, blood was seen spilled all over the sensor and centrifuge compartment as shown in [Figure 1]. Leakage was noticed from the channel at the point shown in [Figure 2] and [Figure 3]. Both the kits were of the same lot no. and expiry date (04U2117 and 01/04/2014, respectively) and more than 40 kits of the same lot were used during that period. Kits were installed by two different trained and experienced persons. No kinks were noticed in tubing during the kit installation. Details of the events were communicated to the manufacturer/distributor to look into the transport and storage conditions during shipping of the kits.
Figure 1: Blood seen over sensor and centrifuge compartment

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Figure 2: Site of leakage from channel (horizontal view)

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Figure 3: Site of leakage from channel (vertical view)

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Trima Accel cell separator is provided with a fluid leak detector in the form of a strip of moisture-sensitive material running down the center of the back wall and floor of the centrifuge chamber which senses even 0.5 ml leakage in the centrifuge compartment [1] and an audio-visual alarm is generated either during priming or initial stage of the procedure if kit ruptures at the level of multilumen tubing as it leads to prompt filling of fluid in centrifuge compartment. But in our procedures, leakage was from the upper end of channel, and the possible explanations for the delay of alarm could be either because of small size of leakage leading to delayed reach of moisture to the sensor or leakage itself may have appeared late in the procedures and operator did not record any decrease in pressure in the return line before the alarm was raised by the cell separator. As procedure was terminated without rinse back, donor was suggested not to donate for next 3 months. [2] However, there is need for improved alarm detection system for improved quality of the product and donor safety.

 
   References Top

1.Trima A. Operator's manual, for version 5.0-5.1; Lakewood; USA, Gambro BCT, Inc; 2004;2:6-11.  Back to cited text no. 1
    
2.Saran RK. Apheresis, Transfusion medicine, Technical Manual. 2 nd ed. New Delhi, India: Directorate General of Health Services (DGHS), Ministry of Health and Family Welfare, Government of India; 2003. p. 236  Back to cited text no. 2
    

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Correspondence Address:
Gopal Patidar
Department of Transfusion Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh - 160 012
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-6247.126703

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    Figures

  [Figure 1], [Figure 2], [Figure 3]



 

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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006