| CASE REPORT |
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| Year : 2018 | Volume
: 12
| Issue : 1 | Page : 89-92 |
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Detection of antibodies to co-trimoxazole (preservative drug) interfering with routine red cell antibody screening
Deepti Sachan, S Aswin Kumar
Department of Transfusion Medicine, Global Health City, Chennai, Tamil Nadu, India
Correspondence Address:
Deepti Sachan
Department of Transfusion Medicine, Global Health City, #439, Cheran Nagar, Perumbakkam, Chennai, Tamil Nadu
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ajts.AJTS_119_16
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Drug-dependent antibodies can rarely cause interference in pretransfusion antibody screening. The diluents for commercial reagent red blood cells contain different antibiotics, such as chloramphenicol, neomycin sulfate, and gentamycin as a preservative. The presence of antibodies to a given drug in patient may lead to positive results when performing antibody identification. We present a rare case of detection of anti-co-trimoxazole antibody during routine antibody screening in a female patient undergoing neurosurgery. These antibodies mimicked as antibody against high-frequency red cell antigens reacting in both saline phase as well as antiglobulin phase. Anti-co-trimoxazole antibody was confirmed by repeating antibody screen using reagent red cells of different manufacturers with and without co-trimoxazole drug as preservative as well as using washed red cell panels. There were no associated clinical or laboratory evidence of hemolysis.
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