Asian Journal of Transfusion Science
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Year : 2020  |  Volume : 14  |  Issue : 1  |  Page : 60-62

A rare case of naturally occurring allo anti-Jk(a) missed in manual screening test on tube method

1 Lok Samarpan Regional Blood Center, Surat, Gujarat, India
2 Department of Application, Immucor (India), New Delhi, India

Correspondence Address:
Dr. Sanmukh R Joshi
Lok Samarpan Regional Blood Center, Mini Bazar, Varachha Road, Surat - 395 006, Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ajts.AJTS_104_19

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Background: Antibodies to the Kidd blood group are mainly red blood cell (RBC) immune, but a few reports on naturally occurring antibodies have been documented. Aim: The aim of this study is to study the anti-Jk(a) for its unusual reactivity with different serological methods. Materials and Methods: Donor's plasma was tested with RBCs from in house donors and commercial panels by manual and automated devices. Results: A 36-year-old male blood donor with naturally occurring anti-Jk(a) is detected by solid-phase assays and the gel card technique but not by the tube method. The IgG antibody with the titer of >32 was not a complement-fixing hemolysin, showed a reduced reactivity with enzyme-treated RBCs, and was detectable through 8 months' follow-up period. The donor was typed as (Jk(a−). Conclusion: An unusual naturally occurring anti-Jk(a) detected by solid-phase red-cell adherence but not reacting by tube technique reflected on the sensitivity of the methods used.

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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006