Asian Journal of Transfusion Science
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Year : 2020  |  Volume : 14  |  Issue : 2  |  Page : 203-205

Therapeutic plasma exchange: A life-saving modality in Wegener's granulomatosis

1 Department of Transfusion Medicine, KGMU, Lucknow, Uttar Pradesh, India
2 Department of Radiodiagnosis, Dr. RML institute of Medical Sciences, Lucknow, Uttar Pradesh, India
3 Department of Medicine, KGMU, Lucknow, Uttar Pradesh, India

Correspondence Address:
Dr. Tulika Chandra
Department of Transfusion Medicine, King George's Medical University, Lucknow, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ajts.AJTS_89_19

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We report a case of Wegener's granulomatosis (WG) who very well responded to the combination strategy of therapeutic plasma exchange (TPE) and immunosuppression. The patient was a 38-year-old female, diagnosed with severe form of WG. A total of seven cycles was performed with 1.3 total plasma volumes (TPVs) on every alternate day. Standard induction therapy was also started that comprised of a combination of 500 mg intravenous (i.v.) cyclophosphamide and methylprednisolone 1 g slow i.v. daily for 3 days followed by oral prednisolone 60 mg daily for 4 weeks. After seven cycles of TPE, the patient improved and hence TPE was stopped.

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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006