Asian Journal of Transfusion Science
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Year : 2021  |  Volume : 15  |  Issue : 2  |  Page : 233-236

Coomb's negative cold agglutinin disease: A rare report of an incidentally detected case

1 Department of Pathology, Military Hospital, Roorkee, Uttarakhand, India
2 Colonel's Clinic, Roorkee, Uttarakhand, India
3 Department of Lab Medicine, Military Hospital, Roorkee, Uttarakhand, India
4 Dept of Pathology and Lab Medicine, Army Hospital (Research and Referral), New Delhi, India

Correspondence Address:
Dr. K V Vinu Balraam
Department of Pathology, Military Hospital, Roorkee - 247 667, Uttarakhand
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ajts.AJTS_78_20

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Cold agglutinin disease (CAD) is a rare type of autoimmune hemolytic anemia which usually results due to production of immunoglobulin M-type autoantibody against the I/i and H antigens on red blood cell membrane. They can be idiopathic or may be due to underlying lymphoproliferative disorders or atypical infections. It can have a varied presentation ranging from being incidentally detected to being totally transfusion dependent for a longer or shorter duration. Several factors play a role in determining the ability of cold agglutinins in inducing hemolysis such as antibody concentration and temperature. Here, we present a 54-year-old patient, a known case of chronic obstructive pulmonary disease who was admitted to our hospital in the winter months as a case of alcohol withdrawal syndrome. During the course of the stay, the patient developed respiratory insufficiency and went into Type II respiratory failure and hematological investigations revealed features of CAD.

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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006