| CASE REPORT |
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| Year : 2021 | Volume
: 15
| Issue : 2 | Page : 247-249 |
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Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
Minal Wasnik1, Saurabh Lahare1, Tushar Jagzape2, Ramesh Kumar Chandrakar1
1 Department of Transfusion Medicine and Blood Bank, AIIMS, Raipur, Chhattisgarh, India
2 Department of Pediatrics, AIIMS, Raipur, Chhattisgarh, India
Correspondence Address:
Minal Wasnik
Department of Transfusion Medicine and Blood Bank, AIIMS, Raipur, Chhattisgarh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ajts.AJTS_74_19
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Autoimmune hemolytic anemia (AIHA) is characterized by the presence of antibodies directed against self-antigens on red blood cells (RBCs) leading to progressive RBC destruction along with reduced red cell survival. Mixed-type AIHA is characterized by the presence of both warm and cold-autoantibodies. These autoantibodies may cause blood-group discrepancy or cross-match incompatibility leading to delay in arranging suitable blood unit for transfusion. The detection of autoantibodies by monospecific-direct antiglobulin test showing positive reaction on immunoglobulin G and C3d and presence of cold-agglutinins leads to the diagnosis. We report a rare case of mixed AIHA in a 15 years female showing severe anemia, blood group discrepancy, and cross-match incompatibility. She received transfusion of least incompatible packed RBCs without any untoward effect.
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