Asian Journal of Transfusion Science
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Year : 2021  |  Volume : 15  |  Issue : 2  |  Page : 247-249

Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient

1 Department of Transfusion Medicine and Blood Bank, AIIMS, Raipur, Chhattisgarh, India
2 Department of Pediatrics, AIIMS, Raipur, Chhattisgarh, India

Correspondence Address:
Minal Wasnik
Department of Transfusion Medicine and Blood Bank, AIIMS, Raipur, Chhattisgarh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ajts.AJTS_74_19

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Autoimmune hemolytic anemia (AIHA) is characterized by the presence of antibodies directed against self-antigens on red blood cells (RBCs) leading to progressive RBC destruction along with reduced red cell survival. Mixed-type AIHA is characterized by the presence of both warm and cold-autoantibodies. These autoantibodies may cause blood-group discrepancy or cross-match incompatibility leading to delay in arranging suitable blood unit for transfusion. The detection of autoantibodies by monospecific-direct antiglobulin test showing positive reaction on immunoglobulin G and C3d and presence of cold-agglutinins leads to the diagnosis. We report a rare case of mixed AIHA in a 15 years female showing severe anemia, blood group discrepancy, and cross-match incompatibility. She received transfusion of least incompatible packed RBCs without any untoward effect.

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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006