| CASE REPORT |
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| Year : 2022 | Volume
: 16
| Issue : 1 | Page : 135-139 |
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Passenger Lymphocyte Syndrome as a rare cause of hemolysis in a patient after small intestine transplantation, A case report and review of the literature
Edalat Zarei1, Mojtaba Shafiekhani2, Nazanin Azadeh1, Alireza Shamsaeefar1, Mahnaz Lotfi1, Mahbube Ahrami1, Amirhassan Rabbani3, Hamed Nikoupour1
1 Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2 Shiraz Transplant Research Center; Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
3 Department of Transplant and Hepatobiliary Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Correspondence Address:
Hamed Nikoupour
Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ajts.ajts_18_21
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Passenger lymphocyte syndrome (PLS) is a well-described phenomenon causing immune hemolytic anemia, mostly in non-ABO identical transplantations. The syndrome occurs when donor lymphocytes produce antibodies against the recipient's red blood cells. Although the syndrome is usually self-limited, further management with blood transfusions, immunosuppression, or plasmapheresis might be needed. A 23-year-old female with AB+ blood group underwent small intestine transplantation from a deceased donor with O+ blood group. She received rituximab, thymoglobin, and methylprednisolone as immunosuppressive induction. In the 9th postoperation day, she developed hemolysis which was primarily managed with blood transfusions and finally ceased by plasmapheresis and intravenous immunoglobulin. Few cases of PLS have been previously described in intestinal transplantation recipients. Correct diagnosis and management prevents severe hemolysis outcomes. Previous cases have been successfully treated with a combination of immune suppression, plasma exchange, and transfusions.
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