Naturally occurring anti-P1 with high thermal amplitude complicating ABO blood grouping Ferdowsi S, Mohammadi S, Ahmadnezhad M, Herfat F, Rezvani A, Eshghi P, Oodi A, - J Indian Prosthodont Soc

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CASE REPORT

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Naturally occurring anti-P1 with high thermal amplitude complicating ABO blood grouping Shirin Ferdowsi¹, Saeed Mohammadi², Moharram Ahmadnezhad¹, Fahimeh Herfat¹, Azita Rezvani¹, Peyman Eshghi³, Arezoo Oodi¹ ¹ Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran ² Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine; Hematology-Oncology and Stem Cell Transplantation Research Center; Research Institute for Oncology, Hematology and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran ³ Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine; Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Correspondence Address: Arezoo Oodi, Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran Iran Source of Support: None, Conflict of Interest: None DOI: 10.4103/ajts.ajts_12_21

Anti-P1 is immunoglobulin M type and occurs naturally; it is often detected as a weak- and cold-reactive antibody. However, in rare cases, it is reactive at 37°C or shows hemolytic transfusion reactions. The presence of high thermal amplitude of anti-P1 cannot be ignored and requires cross-match compatible red blood cells for transfusion. In the present study, we report three cases with ABO discrepancy due to anti-P1 that was identified as a cold-reacting antibody with high thermal amplitude.

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    -  Ahmadnezhad M
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