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Humoral response to SARS-COV-2 in COVID-19-recovered patients and correlation with various factors
Tulika Chandra1, D Himanshu2, Pradeep Kumar Maurya1, Mallika Agarwal3, Saurabh Pandey4
1 Department of Transfusion Medicine, King George's M.U, Lucknow, Uttar Pradesh, India
2 Department of Medicine, King George's M.U, Lucknow, Uttar Pradesh, India
3 Era Medical College, Lucknow, Uttar Pradesh, India
4 Department of Internal Medicine, King George's M.U, Lucknow, Uttar Pradesh, India
Correspondence Address:
Tulika Chandra,
Department of Transfusion Medicine, King George's M.U, Lucknow, Uttar Pradesh
India
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/ajts.ajts_56_21
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CONTEXT: On exposure to SARS-CoV-2 in participants anti-SARS-CoV-2 antibodies are expected to appear as a humoral response. Furthermore, various factors affect their expression.
AIMS: The aim of this study is to investigate the humoral response of COVID-19-recovered participants and correlation with duration of disease, duration of COVID positive to date of test, occupation, blood group, age group, weight, gender, and symptoms of anti-SARS-CoV-2 antibodies.
SETTINGS AND DESIGN: This prospective observational study was conducted at the Department of Transfusion Medicine, at a tertiary care center in North India.
METHODS: Seventy-two participants were tested for anti-SARS-CoV-2 antibodies on chemiluminescent microparticle immunoassay postgetting COVID negative.
STATISTICAL ANALYSIS: The data were analyzed using Kruskal–Wallis and Mann–Whitney test. To correlate variables such as duration of disease, duration of COVID positive to date of test of immunoglobulin G (IgG), occupation, blood group, weight, gender, symptoms, and age group Chi-square test were used.
RESULTS: The correlation of anti-SARS-CoV-2 antibodies with a duration of disease (P > 0.05), duration of COVID positive to date of test of IgG (P > 0.05), occupation (P > 0.05), blood group (P > 0.05), weight (P > 0.05), gender (P > 0.05), and symptoms (P > 0.05) is insignificant and whereas significant correlation with age group (P < 0.05) seen.
CONCLUSIONS: A significant correlation was seen in anti-SARS-COV-2 antibodies and age group. Higher antibody levels were seen in participants of the upper extreme age group (50–60 years).
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