Asian Journal of Transfusion Science
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A patient with probable rare blood Group B(A) phenotype

1 Department of Blood Bank, Regency Hospital Limited, Kanpur, Uttar Pradesh, India
2 Department of Transfusion Medicine, Sparsh MultiSpecialty Hospital, Bengaluru, Karnataka, India
3 Department of Transfusion Medicine, AIIMS, Bhopal, Madhya Pradesh, India

Correspondence Address:
P M. Bala Bhasker,
Department of Transfusion Medicine, Sparsh MultiSpecialty Hospital, Bengaluru, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ajts.ajts_166_21

Karl Landsteiner discovered ABO blood group system in the early 20th century, but still, uncertainty remains in immunohematology while detection of ABO subgroups or weaker variants. The presence of weak subgroups in patient samples gives rise to the discrepancy in forward (cell) and reverse (serum) grouping. We here report a case of the B(A) phenotype in a patient who was diagnosed with chronic liver disease with acute pancreatitis, requiring packed red blood cells due to anemia. The blood group discrepancy was resolved using serological testing and adsorption–elution technique. Blood grouping by the tube technique showed 2+ agglutination with anti-A antisera, strong agglutination (4+) with anti-B, anti-AB, and anti-D antisera, 4+ agglutination with A1 cells, and no agglutination with B cells and O cells in serum grouping. Results for both eluate and last wash were negative to all the donor cells used. This report highlights the importance of cell and serum grouping, solving blood group discrepancy, and also in providing crossmatch compatible blood components without delay. This rare phenotype in a patient is the first of its kind reported from India.

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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006