Asian Journal of Transfusion Science
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Platelet count in impedance-based hematology analyzer: Beware of trap!

1 Department of Pathology, JSS Medical College, Mysore, Karnataka, India
2 Department of Hematology, Anand Diagnostic Laboratory, Bengaluru, Karnataka, India

Correspondence Address:
Vani Krishnamurthy,
#70, Prakruthi, BEML 2nd Stage, Rajarajeshwari Nagara, Mysuru - 570 022, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ajts.ajts_65_21

Among the blood counts, platelet count is most often reported with inconsistency. Many of the analyzers work on electrical impedance principle for red blood cell (RBC) and platelet counting. However, with this technology, factors such as fragmented RBCs, microcytes, cytoplasmic fragments of leukemic cells, lipid particles, fungal yeast forms, and bacteria are known to interfere with platelet count and give spuriously elevated platelet counts. A 72-year-old male was admitted for the treatment of dengue infection who had serial platelet count monitoring. He had an initial platelet count of 48,000/cumm which suddenly improved to 2.6 lakhs within 6 h without any platelet transfusion. Peripheral smear however did not correlate with the machine-derived count. Repeat test after 6 h yielded a result of 56,000/cumm which correlated well with the peripheral smear. This falsely elevated count was due to the presence of lipid particles as the sample was drawn in the postprandial state.

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2006 - Asian Journal of Transfusion Science | Published by Wolters Kluwer - Medknow
Online since 10th November, 2006