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An autoantibody to Rh-Ce protein causing positive direct antiglobulin test in a healthy blood donor
Yesha Nirmal Parikh1, Mayuri M Vekariya2, Vasant Kaushik Gondaliya1, Manisha M Rajapara2, Sanmukh Ratilal Joshi2
1 Department of Blood Bank, S. G. Shalby Hospital, Ahmedabad, Gujarat, India
2 Research Section, Lok Samarpan Raktadan Kendra and Research Centre, Surat, Gujarat, India
Correspondence Address:
Sanmukh Ratilal Joshi,
Lok Samarpan Raktadan Kendra and Research Centre, Mini Bazar, Varachha Road, Surat - 395 006, Gujarat
India
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/ajts.ajts_106_22
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A positive direct antiglobulin test (DAT) is of diagnostic feature for the patient with autoimmune hemolytic anemia (AIHA). However, on rare occasions, for obscure reasons, it is found among healthy blood donors. The present report is aimed to elucidate serological and immunological characteristics of such autoantibody in a healthy donor aged 62 years found with positive DAT. There was no history of Leishmaniasis, nor having a significant illness. His red blood cells (RBCs) showed incompatible cross-match results with every recipient tested in the antiglobulin phase. He was found to be DAT+. As his plasma had very little presence of autoantibody, hence was augmented by elution from his in vivo sensitized RBCs for the study. Autoantibody with immunoglobulin IgG showed predominant specificity of anti-Ce. It is certainly a rare case of autoantibody to RhCe compound antigen yet being innocuous in a healthy blood donor with a positive DAT.
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