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A method for selecting P antigen-negative red cell units for patients with paroxysmal cold hemoglobinuria
Geethika Sajeewani Manchanayake
Blood Bank, District General Hospital, Monaragala, Sri Lanka
Correspondence Address:
Geethika Sajeewani Manchanayake,
No. 572, Waguruwela, Welpalla
Sri Lanka
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/ajts.AJTS_65_19
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In the absence of specific antisera and molecular typing technique, selection of P antigen-negative red cell unit is a challenge. This article explains a new technique that can be used in emergency situations to screen P antigen-negative red cell unit for the transfusion of patients with paroxysmal cold hemoglobinuria tested positive for Donath-Landsteiner antibody. The technique is based on the theory behind the Donath-Landsteiner test, and it can be performed even in a transfusion laboratory with minimum facilities.
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