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The impact of factors on autologous peripheral blood stem cell collection efficiency
Gorana Ahmetovic-Karic1, Elma Catovic-Baralija1, Lejla Ibricevic-Balic2
1 Department for Hemapheresis with Tissue Bank, Blood Transfusion Institute of the Federation of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina
2 Department for Stem Cell Transplantation, Hematology Clinic, University Clinical Centre, Sarajevo, Bosnia and Herzegovina
Correspondence Address:
Gorana Ahmetovic-Karic,
Department for Hemapheresis with Tissue Bank, Blood Transfusion Institute of the Federation of Bosnia and Herzegovina, Cekalusa 86, Sarajevo
Bosnia and Herzegovina
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/ajts.ajts_91_22
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BACKGROUND: Peripheral blood stem cells are used for autologous transplantation in the treatment of hematological diseases. Collection efficiency (CE) is an objective quality parameter used to assess the quality of leukapheresis.
AIM: In this study, we analyzed the affection of various patient and procedural factors on CD34-positive (CD34+) CE in leukapheresis.
SETTINGS AND DESIGN: Demographics, stem cell collection, and laboratory measures from adult autologous donors undergoing leukapheresis, collected from medical records for 7 years, were retrospectively reviewed.
METHODS: A total of 86 consecutive leukapheresis procedures performed on 60 patients (33 males and 27 females) with malignant hematological diseases who are involved in the process of autologous transplantation were included. Various parameters such as diagnosis, sex, age, weight, preprocedural total leukocyte count (TLC), preprocedural absolute CD34+ cell count, preprocedural platelet cell count, preprocedural hematocrit, blood flow, and blood volume processed on CE were evaluated. The results were compared using regression analysis, statistical comparisons between groups, and statistical correlation.
RESULTS: The median CE was 53.6%. Higher preprocedural TLC was associated with lower CE. Preprocedural CD34+ cell count was found to be strongly correlated with the total number of CD34+ cells collected in product.
CONCLUSION: Preprocedural TLC was the factor affecting CE.
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