Asian Journal of Transfusion Science

CASE REPORT
Year
: 2020  |  Volume : 14  |  Issue : 1  |  Page : 70--73

Red blood cell exchange in sickle cell disease patient with multiple alloantibodies


Geet Aggarwal1, Aseem Kumar Tiwari1, Pratibha Dhiman2, Dinesh Arora1, Swati Mehta Pabbi1, Divya Setya1 
1 Department of Transfusion Medicine, Medanta – The Medicity, Gurgaon, Haryana, India
2 Department of Medical Oncology and Hematology, Medanta – The Medicity, Gurgaon, Haryana, India

Correspondence Address:
Dr. Aseem Kumar Tiwari
Department of Transfusion Medicine, Medanta – The Medicity, Sector-38, Gurgaon - 122 001, Haryana
India

There are several reports in medical literature about Red Cell Exchange (RCE) being routinely performed pre-operatively in sickle cell disease patients to provide immediate decrease in HbS concentration and prevent post-operative complications. We would like to present one such case of SCD who also had multiple allo-antibodies and had to undergo hemi-arthroplasty for avascular necrosis of head femur. Grouping and antibody screening was performed using column agglutination technique. 3-cell and 11- cell panel were used for antibody screening and identification, respectively. Automated RBC exchange was performed on apheresis machine Com.Tec using the standard PL1 kit (Fresenius Kabi, Germany). Multiple (anti-c, E) allo-antibodies were identified and successful pre-operative RCE was done with corresponding antigen-negative AHG compatible RBC units. Single RCE procedure reduced HbS concentration from 65% to 25%. The patient underwent uneventful hemi-arthroplasty and was discharged on post-operative day-7. Patient is on regular follow-up and continues to do well two months after the day of surgery. This is possibly the first case report from India, which illustrates successful automated RCE in a SCD patient with alloimmunization.


How to cite this article:
Aggarwal G, Tiwari AK, Dhiman P, Arora D, Pabbi SM, Setya D. Red blood cell exchange in sickle cell disease patient with multiple alloantibodies.Asian J Transfus Sci 2020;14:70-73


How to cite this URL:
Aggarwal G, Tiwari AK, Dhiman P, Arora D, Pabbi SM, Setya D. Red blood cell exchange in sickle cell disease patient with multiple alloantibodies. Asian J Transfus Sci [serial online] 2020 [cited 2022 Sep 26 ];14:70-73
Available from: https://www.ajts.org/article.asp?issn=0973-6247;year=2020;volume=14;issue=1;spage=70;epage=73;aulast=Aggarwal;type=0