Asian Journal of Transfusion Science

CASE REPORT
Year
: 2021  |  Volume : 15  |  Issue : 2  |  Page : 233--236

Coomb's negative cold agglutinin disease: A rare report of an incidentally detected case


K V Vinu Balraam1, Adnan Masood2, Nidhi Garg3, Venkatesan Somasundaram4 
1 Department of Pathology, Military Hospital, Roorkee, Uttarakhand, India
2 Colonel's Clinic, Roorkee, Uttarakhand, India
3 Department of Lab Medicine, Military Hospital, Roorkee, Uttarakhand, India
4 Dept of Pathology and Lab Medicine, Army Hospital (Research and Referral), New Delhi, India

Correspondence Address:
Dr. K V Vinu Balraam
Department of Pathology, Military Hospital, Roorkee - 247 667, Uttarakhand
India

Cold agglutinin disease (CAD) is a rare type of autoimmune hemolytic anemia which usually results due to production of immunoglobulin M-type autoantibody against the I/i and H antigens on red blood cell membrane. They can be idiopathic or may be due to underlying lymphoproliferative disorders or atypical infections. It can have a varied presentation ranging from being incidentally detected to being totally transfusion dependent for a longer or shorter duration. Several factors play a role in determining the ability of cold agglutinins in inducing hemolysis such as antibody concentration and temperature. Here, we present a 54-year-old patient, a known case of chronic obstructive pulmonary disease who was admitted to our hospital in the winter months as a case of alcohol withdrawal syndrome. During the course of the stay, the patient developed respiratory insufficiency and went into Type II respiratory failure and hematological investigations revealed features of CAD.


How to cite this article:
Balraam K V, Masood A, Garg N, Somasundaram V. Coomb's negative cold agglutinin disease: A rare report of an incidentally detected case.Asian J Transfus Sci 2021;15:233-236


How to cite this URL:
Balraam K V, Masood A, Garg N, Somasundaram V. Coomb's negative cold agglutinin disease: A rare report of an incidentally detected case. Asian J Transfus Sci [serial online] 2021 [cited 2022 Jan 18 ];15:233-236
Available from: https://www.ajts.org/article.asp?issn=0973-6247;year=2021;volume=15;issue=2;spage=233;epage=236;aulast=Balraam;type=0