Asian Journal of Transfusion Science

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 16  |  Issue : 2  |  Page : 167--174

Distribution and frequency of principal Rh blood group antigens (D, C, c, E, and e) and their phenotypes in the blood donors attending blood bank in a tertiary care hospital in Barpeta district of Assam


Dipankar Baruah1, Gitali Devi1, Jabin Musfique1, Abhijit Bharali2, Umesh Chandra Dutta1 
1 Department of Pathology, Fakhruddin Ali Ahmed Medical College, Barpeta, Assam, India
2 Multi-Disciplinary Research Unit, Fakhruddin Ali Ahmed Medical College, Barpeta, Assam, India

Correspondence Address:
Dr. Gitali Devi
Department of Pathology, Fakhruddin Ali Ahmed Medical College, Barpeta, Assam
India

BACKGROUND: The ABO and Rhesus grouping system antigens have been found to have the highest immunogenicity and propensity to produce alloantibodies that cause most of the transfusion reactions. The Rhesus antigens that produce most of the immunogenic transfusion reactions are D, C, c, E, and e. Knowledge of the distribution of these Rh antigens in a population helps to render compatible blood in alloimmunized patients. AIM: The aim was to study the distribution and frequency of principal Rh blood group antigens (D, C, c, E, and e) and their phenotypes in the blood donors attending blood bank in a tertiary care hospital in Barpeta district of Assam. MATERIALS AND METHODS: The study was conducted in 315 voluntary blood donors in the blood bank of a tertiary care center. Rh-D typing was done by conventional tube method. Specific monoclonal antisera, i.e., anti-C, anti-c, anti-E, and anti-e, were used and tests were performed by conventional tube method for detection of the presence of rest of the major Rh antigens. RESULTS: The samples were analyzed for the five major Rhesus antigens. “D” antigen was found to be the most common antigen (99.05%), followed by e (97.14%), C (92.38%), c (51.43%), and E (20.95%). In order of descending frequency, the most common phenotypes were DCCee – 45.71%, DCcee – 30.48%, DCcEe – 11.43%, DccEe – 4.76%, DCcEE – 1.90%, DCCEe – 1.90%, Dccee – 1.90%, DCCEE – 0.95%, and dccee – 0.95%. CONCLUSION: D antigen is the most common antigen in our study population, whereas “e” antigen is the most common in most of the studies done from other parts of India. Data on frequencies of major Rh antigens in the local donor population will help in transfusing alloimmunized patients with corresponding antibody-negative blood ensuring blood safety.


How to cite this article:
Baruah D, Devi G, Musfique J, Bharali A, Dutta UC. Distribution and frequency of principal Rh blood group antigens (D, C, c, E, and e) and their phenotypes in the blood donors attending blood bank in a tertiary care hospital in Barpeta district of Assam.Asian J Transfus Sci 2022;16:167-174


How to cite this URL:
Baruah D, Devi G, Musfique J, Bharali A, Dutta UC. Distribution and frequency of principal Rh blood group antigens (D, C, c, E, and e) and their phenotypes in the blood donors attending blood bank in a tertiary care hospital in Barpeta district of Assam. Asian J Transfus Sci [serial online] 2022 [cited 2022 Dec 5 ];16:167-174
Available from: https://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=2;spage=167;epage=174;aulast=Baruah;type=0